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Laboratory of Drug Discovery

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Development of UHPLC-MS/MS Method for Indirubin-3′-Oxime Derivative as a Novel FLT3 Inhibitor and Pharmacokinetic Study in Rats
  • AuthorNa Yoon Kim, Yong-Chul Kim, Yoon Gyoon Kim
  • Year2020/1
  • SourceMolecules

Chemical Characterization and Biological Activity Data for a Novel Indirubin Derivative, LDD-1819
  • AuthorWoong-Hee Kim, Pyeonghwa Jeong, Seon-Wook Kim, Haaglim Cho, Jeong-min Lee, Shinae Seo, Haihong Shen, Youngkeun Ahn, Da-Woon Jung, Yong-Chul Kim, Darren R Williams
  • Year2019/8/9
  • SourceData in Brief

Involvement of the P2X7 receptor in the migration and metastasis of tamoxifen-resistant breast cancer: effects on small extracellular vesicles production
  • AuthorMiso Park, Jieun Kim, Nguyen TT Phuong, Jung Gyu Park, Jin-Hee Park, Yong-Chul Kim, Moon Chang Baek, Sung Chul Lim, Keon Wook Kang
  • Year2019/8/12
  • SourceScientific reports

A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity
  • AuthorWoong-Hee Kim, Pyeonghwa Jeong, Seon-Wook Kim, Haaglim Cho, Jeong-min Lee, Shinae Seo, Haihong Shen, Youngkeun Ahn, Da-Woon Jung, Yong-Chul Kim, Darren R Williams
  • Year2019/7/1
  • SourceBioorganic & medicinal chemistry

Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment
  • AuthorPyeonghwa Jeong, Soo-Kyung Kim, Quanjie Li, Su-jin Oh, Seonil Son, Guangju Chen, Hongwei Tan, Siwon Kim, Jong-Hyun Park, Ki Duk Park, Yeo Ok Kim, Myung Ha Yoon, Yong-Chul Kim, William Goddard III
  • Year2019/10/17
  • SourceChemMedChem

Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and–pyrimidines
  • AuthorJi-seong Yoon, Dnyandev B Jarhad, Gyudong Kim, Akshata Nayak, Long Xuan Zhao, Jinha Yu, Hong-Rae Kim, Ji Yun Lee, Varughese A Mulamoottil, Girish Chandra, Woong Sub Byun, Sang Kook Lee, Yong-Chul Kim, Lak Shin Jeong
  • Year2018/7/15
  • SourceEuropean journal of medicinal chemistry

Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells
  • Authorseung-Hwa Kwak, Seungheon Shin, Ji-Hyun Lee, Jin-Kyoung Shim, Minjeong Kim, So-Deok Lee, Aram Lee, Jinsu Bae, Jin-Hee Park, Aliaa Abdelrahman, Christa E Müller, Steve K Cho, Seok-Gu Kang, Myung Ae Bae, Jung Yoon Yang, Hyojin Ko, William A Goddard III, Yong-Chul Kim
  • Year2018/5/10
  • SourceEuropean journal of medicinal chemistry

Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia
  • AuthorHyo Jeong Lee, Jungeun Lee, Pyeonghwa Jeong, Jungil Choi, Juhwa Baek, Su Jin Ahn, Yeongyu Moon, Jeong Doo Heo, Young Hee Choi, Young-Won Chin, Yong-Chul Kim, Sun-Young Han
  • Year2018/1/2
  • SourceOncotarget

Towards a novel class of multitarget-directed ligands: dual P2X7–NMDA receptor antagonists
  • AuthorOlga Karoutzou, Seung-Hwa Kwak, So-Deok Lee, Daina Martínez-Falguera, Francesc Sureda, Santiago Vázquez, Yong-Chul Kim, Marta Barniol-Xicota
  • Year2018
  • SourceMolecules

Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients
  • AuthorWan-Su Park, Gab-jin Park, Seunghoon Han, Sooho Ban, Moon-Young Park, San-ho Kim, Seon-Myung Kim, Yong-Chul Kim, Hyung Sik Kim, Young G Shin, Dong-Seok Yim
  • Year2017/8/1
  • SourceCancer chemotherapy and pharmacology
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